Endocrine Abstracts

The past decade, epidemiological studies have associated disturbances of the biological clock, as occurs in shift work, with low bone mineral density and increased fracture risk. As a large part of the working population participates in shift work (e.g. almost 30% of workers in the U.S.), this demonstrates the need for further research on the risk of skeletal disorders associated with circadian disturbances. In this study, we aimed to investigate to what extent rhythmicity exi...

Sclerostin is a major negative regulator of osteoblastic activity at tissue level. Serum sclerostin levels have been associated with bone mineral density and increased fracture risk. However, the relation between serum levels and expression on tissue levels is unknown. The aim of this study was to investigate this relationship. We used serum samples and bone biopsies from 26 patients that were available from a large randomised clinical trial, investigating with the effect of r...